Yes. POPcon uses standard SMTP to deliver mail to Exchange, which makes it compatible with all Exchange versions including:
- Exchange 2016 / 2013 / 2010 / 2007 / 2003 / 2000 / 5.5
- All SBS (Small Business Server) editions
- Lotus Notes
- Tobit David
- Any other mail server that accepts standard SMTP on port 25
POPcon does not use Exchange-specific APIs — it communicates via SMTP, so version upgrades do not affect POPcon's compatibility.
Background: Does Exchange Server have a built-in POP3 connector? — why the SBS POP3 Connector did not survive the move to standalone Exchange.