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"550 5.7.1 Unable to relay" error from Exchange

This error means your internet domain has not been added to Exchange's list of accepted domains. Exchange rejects delivery for any domain it does not own.

Exchange 2007 / 2010 / 2013 / 2016

  1. Open the Exchange Management Console / Admin Center.
  2. Navigate to Organization Configuration > Hub Transport > Accepted Domains (or Mail Flow > Accepted Domains).
  3. Click New Accepted Domain.
  4. Enter your internet domain name (e.g. yourcompany.com) and select Authoritative Domain.
  5. Click Finish and retry.

Exchange 2003

Add your domain to the Default Policy under Recipients > Recipient Policies in Exchange System Manager.

Screenshots — step by step

Exchange 2007 Accepted Domains List
Exchange 2007 Accepted Domains List
Exchange 2007 new accepted domains
Exchange 2007 new accepted domains

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